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ㆍ 제목 치료 목적의 유전자 편집: 앞으로의 전망과 해결해야 할 과제들 Therapeutic genome editing: prospects and challenges
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 제목 

 Therapeutic genome editing: prospects and challenges​

 학술지 

 Nature Medicine​

 발간년도 

 2015; 21(2)​  

 저자 

  •  David Benjamin Turitz Cox,
  • Randall Jeffrey Platt
  • Feng Zhang
  •  

    http://www.nature.com/nm/journal/v21/n2/full/nm.3793.html 

     

     

    Abstract

    Recent advances in the development of genome editing technologies based on programmable nucleases have substantially improved our ability to make precise changes in the genomes of eukaryotic cells. Genome editing is already broadening our ability to elucidate the contribution of genetics to disease by facilitating the creation of more accurate cellular and animal models of pathological processes. A particularly tantalizing application of programmable nucleases is the potential to directly correct genetic mutations in affected tissues and cells to treat diseases that are refractory to traditional therapies. Here we discuss current progress toward developing programmable nuclease–based therapies as well as future prospects and challenges.

     

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